Michela Matteoli
Professore Ordinario
02.50317097/95/98
Teaching
Responsabile del Corso di Neuropsicofarmacologia per Laurea Magistrale in Biotecnologie Mediche e Medicina Molecolare (indirizzo Neuroscienze);
Responsabile del Corso di Farmacologia per Educatori Professionali;
Responsabile del modulo di Neuropsicofarmacologia - Corso di Farmacologia per Medicina e Chirurgia (sede S.Donato);
Coordinatore del Corso di laurea in Educazione Professionale (sede Don Gnocchi);
Membro del Consiglio dei Docenti della Scuola di Specialitā in Farmacologia Chemioterapia e Tossicologia Medica;
Membro del Consiglio dei Docenti della Scuola di Dottorato in Farmacologia Chemioterapia e Tossicologia Medica.
Research lines
RESEARCH GROUP MEMBERS:
Michela Matteoli
Claudia Verderio, CNR Researcher
Elisabetta Menna, Postdoctoral Fellow
Davide Pozzi, Postdoctoral Fellow
Steven Condliffe, Postdoctoral Fellow
Cinzia Cagnoli, Postdoctoral Fellow
Fabio Bianco, Postdoctoral Fellow
Molecular and cellular mechanisms of synapse formation and function
Our laboratory has actively contributed in defining the main events occurring during synaptogenesis between hippocampal cultures (Matteoli et al., TICB 2004). The process of synaptogenesis between neurons is investigated in primary cultures of embryonic hippocampal neurons.
Cell-to-cell communication in brain
Glial cells are the most abundant cell population in the CNS. They actively interact with neuronal cells and play a crucial role in controlling synaptogenesis and modulating fully working synaptic networks, as well as in synaptic plasticity phenomena.
Methods
Primary culturing of neurons, astrocytes, microglia (pure or in combination).
Confocal microscopy.
Basic biochemistry tecnhiques, cell fractionation, immunoisolation of vesicles.
Single cell calcium imaging.
Electrophysiology.
Videomicroscopy.
Publications
  • Activity-dependent phosphorylation of Ser 187 is required for SNAP-25 negative modulation of neuronal voltage-gated calcium channels.
  • journal: Proceedings of the National Academy of Sciences
    journal no.: 105/1
    year: 2008
    pages: 323-328
  • Heterogeneous expression of SNAP-25 in rat and human brain.
  • journal: The Journal of Comparative Neurology
    journal no.: 506/3
    year: 2008
    pages: 373-386
  • Calpain activity contributes to the control of SNAP-25 levels in neurons.
  • journal: Molecular and Cellular Neruoscience
    journal no.: 39/3
    year: 2008
    pages: 314-323
  • Teaching in the operative room: the benefit of daysurgery on surgical trainees.
  • journal: G. Chir.
    journal no.: 29/11-12
    year: 2008
    pages: 511-514
  • Uptake and recyclic of pro-BDNF for transmitter-induced secretion by cortical astrocytes.
  • journal: Journal of Cell Biology
    journal no.: 183
    year: 2008
    pages: 213-221
  • Unique luminal localization of VGAT-C terminus allows for selective labeling of active cortical GABAergic synapses.
  • journal: The Journal of Neuroscience
    journal no.: 28/49
    year: 2008
    pages: 13125-13131.
  • The synaptic split of SNAP-25: different roles in glutamatergic and GABAergic neurons ?
  • journal: Neuroscience
    journal no.: 158/1
    year: 2009
    pages: 223-230
  • Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF).
  • journal: PLoS Biol.
    journal no.: 7/6
    year: 2009
    pages: e1000138
  • Controlled deposition of cells in sealed microfluidics using flow velocity boundaries.
  • journal: Lab. on a Chip.
    journal no.: 9/10
    year: 2009
    pages: 1395-1402
  • Neuropsycological gender differences in healthy individuals and pediatric neurodevelopmental disorders: a role for SNAP-25.
  • journal: Medical hypotheses
    journal no.: 73/6
    year: 2009
    pages: 978-980
  • VGLUT1 and VGAT are sorted to the same population of synaptic vesicles in subsets of cortical axon terminals.
  • journal: Journal of Neurochemistry.
    journal no.: 110/5
    year: 2009
    pages: 1538-1546.
  • Different properties of P2X(7) receptor in hippocampal and cortical astrocytes.
  • journal: Purinergic signalling.
    journal no.: 5/2
    year: 2009
    pages: 233-240
  • Acid sphingomyelinase activity triggers microparticle release from glial cells.
  • journal: EMBO Journal
    journal no.: 28/8
    year: 2009
    pages: 1043-1054.
  • Intrisic calcium dynamics control botulinum toxin A susceptibility in distinct neuronal populations.
  • journal: Cell Calcium
    journal no.: 47/5
    year: 2009
    pages: 419-424.
  • A microfluidic device for depositing and addressing two cell population communication capability.
  • journal: Biomed. Microdevices
    journal no.: 12/2
    year: 2010
    pages: 275-282
  • Cholesterol reduction impairs exocytosis of synaptic vesicles.
  • journal: Journal of Cell Science
    journal no.: 123/Pt4
    year: 2010
    pages: 595-605
  • Endogenous SNAP-25 regulates native voltage-gated calcium channels in glutamatergic neurons.
  • journal: Journal of Biological Chemistry
    journal no.: 285/32
    year: 2010
    pages: 24968-24976
  • Overflow microfluidic networks for open and closed cell cultures on chip.
  • journal: Analytical Chemistry
    journal no.: 82/9
    year: 2010
    pages: 3936-3942
  • The Eps8/IRSp53/VASP network differentially controls actin capping and bundling in filopodia formation.
  • journal: PLoS Computational Biology
    journal no.: 7/7
    year: 2010
    pages: e1002088,1-14
  • "Inactivation kinetics of voltage-gated calcium channels in glutamatergic neurons are influenced by SNAP-25".
  • journal: Channels
    journal no.: 5/4
    year: 2011
    pages: 304-307
  • From filopodia to synapses: the role of actin-capping and anti-capping proteins.
  • journal: European Journal of Neuroscience
    journal no.: 34/10
    year: 2011
    pages: 1655-1662
  • Hydrogel for cell housing in the brain and in the spinal cord.
  • journal: J. Artif. Organs
    journal no.: 34/3
    year: 2011
    pages: 295-303
  • SNAP-25 single nucleotide polymorphisms are associate with hyperactivity in autism spectrum disorders.
  • journal: Pharmacol. Res.
    journal no.: 64/3
    year: 2011
    pages: 283-288
  • LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool.
  • journal: Journal of Nuroscience
    journal no.: 31/6
    year: 2011
    pages: 2225-2237
  • ATP in neuron-glia bidirectional signalling.
  • journal: Brain Res. Rev.
    journal no.: 66/1-2
    year: 2011
    pages: 106-114.
  • Inactivation kinetics of voltage-gated calcium channels in glutamatergic neurons are influenced by SNAP-25.
  • journal: Channels
    journal no.: 5/4
    year: 2011
    pages: 304-307.
  • Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism.
  • journal: EMBO Journal
    journal no.: 31/5
    year: 2012
    pages: 1231-1240.
  • TI-VAMP/VAMP7 is the SNARE of secretory lysosomes contributing to ATP sevretion from astrocytes.
  • journal: Biology of the Cell
    journal no.: 104/4
    year: 2012
    pages: 213-228
  • Microglial microvesicle secretion and intracellular signaling.
  • journal: Frontiers in Physiology
    journal no.: 3/149
    year: 2012
    pages: 1-11
  • Cracking down on inhibition: selective removal of GABAergic interneurons from hippocampal networks.
  • journal: The Journal of Neuroscience
    journal no.: 32/6
    year: 2012
    pages: 1989-2001.
  • Mutant PrP suppresses glutamatergic neurotransmission in cerebellar granule neurons by impairing.
  • journal: Neuron.
    journal no.: 74/2
    year: 2012
    pages: 300-313
Co-operations
Prof. Pietro De Camilli, HHMI and Dept of Cell Biology, Yale School of Medicine.
Dr. George Augustine, Duke University.
Dr. Thierry Galli, INSERM, Paris.
Prof. Fabio Benfenati, Universitā di Genova.
Dr. Yael Stern Bach, Hebrew University Medical School.
Dr. Giorgio Scita, IFOM, Milano.
 
 
 
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